The expertise of our Mobilisers goes far beyond the Mobilise-D patient groups. Ultimately our findings should benefit anyone with mobility challenges, such as people suffering from Huntington’s Disease. Heiko Gaßner and colleagues explain more in their paper investigating gait variability as digital biomarkers of severity in Huntington’s disease.
In this study, characteristic features of gait in patients with Huntington’s disease (HD) were objectively identified using sensor-based gait analysis. Particularly, gait parameters were correlated to the Unified Huntington’s Disease Rating Scale, total motor score, and total functional capacity. Patients with manifest HD at two German sites (n=43) were included and compared to a cohort of age- and gender-matched controls (n=43). Parameters reflecting gait variability were substantially altered in HD patients and showed strong correlations to the clinical scales. Sensor-based gait variability parameters were identified as the clinically most relevant digital biomarkers for gait impairment in HD. Altered gait variability represents characteristic irregularity of gait in HD and reflects disease severity.
Read the full paper here: https://doi.org/10.1007/s00415-020-09725-3
