Public Newsletter Jan-Aug 2021

Our public newsletter is out now! Stay up to date on what has happened in Mobilise-D over the last few months. This newsletter consists of all our news from January to August 2021. Read it HERE. Remember to FOLLOW us on Facebook, Twitter and LinkedIn.Subscribe to our Newsletter.

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Novartis job opportunity for analysis of wearable sensor data for Digital Mobility Outcomes

Novartis is now looking for a Digital Data Scientist to join their group and participate in their ground-breaking medical research activities that redefine the grammar for medicine in the post-genome era. The Digital Data Scientist in Novartis will understand complex and critical business problems, formulate integrated analytical approach to mine data sources, employ statistical methods…

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Episode 4: The Cyclone Challenge – Mobiliser raising money for PD UK

The day had finally arrived. The day for the Cyclone Challenge Ride. Saturday, July 03, the day mobiliser Alison Yarnall and her friend Naomi were going to ride their bicycles for 108 miles (173,8 km). The day they wanted to raise money for a good cause. The day they raised money for Parkinson’s UK.  The reason why Alison wanted to raise money for Parkinson’s UK by racing 108 miles can be explained by…

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EMA Public Support for Mobilise-D: Follow-up

In the first year of Mobilise-D, we asked the European Medicines Agency (EMA) for Qualification Advice regarding Digital Mobility Outcomes (DMOs). EMA published their first letter of support in April 2020 that publicly endorsed our initial stage in the wider objective of the Mobilise-D consortium to pursue the qualification of Digital Mobility Outcomes (DMOs) as…

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Episode 3: Making a difference in people’s lives – Silvia Del Din awarded a NUAcT Fellowship.

Our Mobilise-D colleague Dr. Silvia Del-Din has always been fascinated by research and the idea of “making a difference in people’s lives”. Here she explains her role in Mobilise-D, her new NUAcT fellowship at Newcastle University, and her perspective on how remote monitoring can revolutionize healthcare.  Silvia (37) was born in Agordo in the North-East of Italy and is a great fan of travelling and hiking. In her professional life, she has been involved in research for more than 10 years now. But how did a young girl from a small town nestled in the Dolomites, end up doing…

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Key challenges in the use & development of digital endpoints from a health technology assessment (HTA) perspective

Digital endpoints offer a great potential to be considered in the HTA framework. So far, however, there is no institutional way in.  On February 15, 2021, IMI Neuronet hosted an online meeting of its working group on health technology assessment (HTA) and regulatory interactions, moderated by Diana O’Rourke from the National Institute for Health and Care Excellence (NICE). The discussions were based around the experiences of three different IMI projects that are…

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Neuronet ECR submission for the virtual Alzheimer Europe Conference is open!

Neuronet invites Early Career Researchers from the Innovative Medicines Initiative’s neurodegeneration research projects to present their work at the upcoming Alzheimer Europe Conference.Applicants whose abstracts are accepted for a Quick Oral or Poster presentation will be granted a free registration to attend the three-day virtual conference. The deadline for submissions is June 30. This will…

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IMI article about our Digital Health Catalyst initiative

The Digital Health Catalyst (DHC) was created by Mobilise-D and IDEA-FAST in response to the growing need for research and application in the area of real-world digital measurements. “The field will require a new generation of personnel from areas including clinical research and application, sensor and hardware development, infrastructure and data handling, data processing and…

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When life gives you lemons, make Lemon Drizzle cake!

Real World Stories – Episode 3: “My balance is elusive advanced Multiple Sclerosis (MS). Always optimistic. Want to walk at least 25 times a month for eight months #2021Walkathon. Love my Travelscoot (The Trike)”. This is the Twitter bio of “Patrick Burke, I walk very slowly”, the inspiration behind the third episode of our Real World Stories.   Patrick (68) is happily married and has three children in their 30s. He is medically…

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Mobilise-D and IDEA-FAST announce the creation of the Digital Health Catalyst (DHC)

Mobilise-D and IDEA-FAST are pleased to announce the creation of the Digital Health Catalyst (DHC). Mobilise-D is working on digital mobility assessment in chronic obstructive pulmonary disease (COPD), Parkinson’s disease (PD), multiple sclerosis (MS) and recovery from proximal femoral fracture (PFF). IDEA-FAST is working to identify digital endpoints to assess fatigue, sleep disturbances and activities…

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– It’s great to exercise myself together with my groups

The dog’s best friends? Humans. The human’s best friend? Umm well, for many that seems to be the sofa – the buns’ best friend. This soft comfortable piece of fabric, encouraging you to be sedentary week in, week out. It becomes a better and better friend as the years go by, keeping you inactive. But did you know that inactivity…

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Public Newsletter 2020

Last year was a turbulent and busy year for Mobilise-D in many ways, and this Public Newsletter highlights some of the most significant news from 2020. Read our Public Newsletter 2020 here.

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In the spotlight: Abolfazl Soltani’s Public PhD defense, Friday, Dec 11

This coming Friday Abolfazl Soltani, one of our Mobilisers from EPFL, Switzerland, will have the public defense of his PhD thesis.  In his PhD work, Abolfazl has focused on accurate walking speed estimation and walking bout detection based on wrist-worn sensors. Although there are many different digital systems that can monitor gait in unsupervised free-living situations such as housekeeping, catching a bus, and shopping, they each have different advantages and disadvantages.   One such system, the Global Navigation Satellite System (GNSS), can measure real-world gait speed accurately, but…

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New publication: A roadmap to inform development, validation and approval of digital mobility outcomes: the Mobilise-D approach

Well known biomarkers such as blood pressure, respiration, temperature, pulse, and pain are frequently used by physicians and other health professionals to describe a patient’s health and disease status. In addition to these ‘signs of life’, there is another important aspect of people’s health and disease status, namely their mobility – how well they walk. Loss of physical mobility, such as reduced walking speed, is a significant feature of many health…

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EMA Public Support for Mobilise-D

In the first year of Mobilise-D, we asked the European Medicines Agency (EMA) for qualification advice for Digital Mobility Outcomes (DMOs). EMA just published their letter of support that publicly endorses our initial stage in the wider objective of the Mobilise-D Consortium to pursue the qualification of Digital Mobility Outcomes (DMOs) as monitoring biomarkers of…

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NIHR NEWS: Monitoring patients’ mobility continues despite new lockdown

Monitoring patients’ mobility during the COVID19 pandemic could easily have been impossible due to lockdown and restrictions such as social distancing. However, this isn’t the case for the Mobilise-D technical validation study (TVS) where 120 participants with chronic obstructive pulmonary disease, Parkinson’s disease, multiple sclerosis, congestive heart failure or hip fracture, along with healthy older adults, will be enrolled. Our test sites in Newcastle and Sheffield have found a way to work around the distancing restrictions to keep the study open, and confirmed that the technical validation…

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[Publication] Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes

Today’s smartwatches and activity bracelets, like FitBit, Apple, and Samsung, have motion sensors that can measure your daily activity. These technologies can tell you how much or little active you are, for example by counting your daily number of steps, heart rate or track your movements with GPS. In both basic and clinical research, similar…

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– I felt Mobilise-D!

REAL WORLD STORIES – Episode 1 Mobility – how well people walk – is an important marker of health. With advanced age, as well as disease and injury, mobility challenges often become prominent. The COVID-19 breakout and the subsequent lockdowns all over the world put severe restrictions on everyone’s mobility. However, as it turns out,…

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[VIDEO] Introducing the Mobilise-D Clinical Trials

One of the many impacts of the COVID-19 lockdown earlier this year, has been the severe restrictions on mobility of both patients and the public. Furthermore, the ability to assess patients’ mobility has suffered as well because of the barriers created between researchers and participants. Being able to remotely monitor patients’ mobility in their natural…

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Mobilise-D’s Claudia Mazzà receives Suffrage Science award 2020!

The Mobilise-D Consortium is incredibly proud that our own WP2 star academic leader, Professor Claudia Mazzà from the University of Sheffield, is a recipient of the Suffrage Science award, celebrating women in science for their scientific achievements and their ability to inspire others. The Suffrage Science scheme was founded by the Medical Research Council’s London Institute…

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Mobilise-D well represented at the Virtual Physiological Human Conference 2020

The Virtual Physiological Human Conference (VPH2020) was held online August 24-28 with several representatives from the Mobilise-D consortium. This year, the focus was on “When models, methods & experiments meet the clinic”. Prof. Claudia Mazzà from the University of Sheffield, Mobilise-D’s Academic Lead of WP2 – Algorithm development and technical validation, chaired the session “Monitoring &…

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Mobilise-D Technical Validation Study has started!

We are tremendously proud to announce that the Mobilise-D Technical Validation Study has officially started recruiting subjects! After the unprecedented times of COVID-19 lock-down that affected the entire world, we are now in a position to come back safely and restart our research in clinical settings. COVID-19 times are not over yet, and therefore we…

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Protocol paper for Mobilise-D scoping review published

Walking limitations are debilitating symptoms in many chronic diseases, and are highly related to quality of life, fall risk, and economic burden. Unsurprisingly, walking ability is a common target of pharmacological or behavioural intervention. Thanks to advances in wearable sensor technologies, it is now possible to objectively monitor how, and how much, patients walk in…

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VIDEO: Mobilise-D matters – now more than ever!

The large-scale social and behavioural changes that happened almost overnight in our day-to-day life due to COVID-19, illustrate the importance of anticipating and developing new ways of patient care. Especially mobility is a telling sign of how well a patient is doing. “Mobility is something that we take for granted until we lose it. And…

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Walking in the lab and a real-world environment with Multiple Sclerosis

Our colleagues from Tel Aviv, the TASMC Mobilisers, studied the quality of walking of people with multiple sclerosis and healthy controls in two environments: a) a well-structured laboratory setting and b) during real-life, everyday walking using 24/7 monitoring.  During every-day walking, the patients took fewer steps, they walked more slowly, and the quality of their…

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New algorithm for gait detection published

FAU-Mobilisers publish a novel algorithm for the detection of gait from continuous inertial sensor data. The approach allows an efficient and precise processing of real-life gait data. This will facilitate the clinical application of mobile gait analysis in free-living conditions. Read the full paper here.

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New publication on gait variability in Huntington’s disease

The expertise of our Mobilisers goes far beyond the Mobilise-D patient groups. Ultimately our findings should benefit anyone with mobility challenges, such as people suffering from Huntington’s Disease. Heiko Gaßner and colleagues explain more in their paper investigating gait variability as digital biomarkers of severity in Huntington’s disease. In this study, characteristic features of gait…

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Technical validation training in Newcastle

The Mobilise-D technical validation training in Newcastle is happening this week (February 24-26th), and Mobilisers from Newcastle and Northumbria University are focused and ready to learn. With assistance from the Universities of Sassari and Sheffield, the Mobilise-D assessors will get a firm grasp on how to properly set up the necessary equipment and how to…

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Center-stage presence of Mobilise-D at the 2020 MobEx Meeting

Mobilise-D featured prominently at this year’s Mobility and Exercise in the Elderly (MobEx) meeting in Bologna, Italy, through two dedicated sessions, one with technical and one with clinical perspectives. MobEx is an annual meeting where a dedicated network of researchers in the fields of mobility, exercise, and their measurement meets and shares experiences, challenges, and…

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Technical validation training session

This January, researchers, academics and clinicians from all over Europe and Israel were welcomed to the Insigneo Motion Capture and Virtual Reality Laboratory at the University of Sheffield for a training session for all the universities and hospitals involved in Work Package 2 ‘Technical validation of a single sensor system’ of the Mobilise-D project. The…

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Invited Mobilise-D Symposium at the Congress of the International Society of Biomechanics in Calgary, Canada

August 3rd 2019 an invited symposium titled “Inertial Measurement Units based methods for mobility assessment in real-world condition” was held at the Congress of the International Society of Biomechanics (ISB) in Calgary, Canada. The aim of the symposium was to survey the most challenging methods, sensor configurations and techniques to detect walking bouts and estimate…

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[Press release] Ground-breaking €50 million digital monitoring project to tackle mobility loss

Imagine being able to monitor patients’ mobility and health with the help of small sensors and personalized algorithms – on a daily basis, without them having to come to a clinic regularly and at predetermined intervals. Impossible? Not according to the Innovation in Medicine Initiative (https://www.imi.europa.eu/), who dedicated 25.4 million euro public money to Mobilise-D,…

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Kick-off Meeting in Newcastle, April 11th 2019

The Mobilise-D project had its official start April 1st this year and on April 11th, the consortium got together to kick the project off to a good start. More than 100 Mobilisers met in Newcastle to better get to know both the project and each other, and to build a strong team that can handle…

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