New publication: A roadmap to inform development, validation and approval of digital mobility outcomes: the Mobilise-D approach

Well known biomarkers such as blood pressure, respiration, temperature, pulse, and pain are frequently used by physicians and other health professionals to describe a patient’s health and disease status. In addition to these ‘signs of life’, there is another important aspect of people’s health and disease status, namely their mobility – how well they walk. Loss of physical mobility, such as reduced walking speed, is a significant feature of many health…

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EMA Public Support for Mobilise-D

In the first year of Mobilise-D, we asked the European Medicines Agency (EMA) for qualification advice for Digital Mobility Outcomes (DMOs). EMA just published their letter of support that publicly endorses our initial stage in the wider objective of the Mobilise-D Consortium to pursue the qualification of Digital Mobility Outcomes (DMOs) as monitoring biomarkers of…

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NIHR NEWS: Monitoring patients’ mobility continues despite new lockdown

Monitoring patients’ mobility during the COVID19 pandemic could easily have been impossible due to lockdown and restrictions such as social distancing. However, this isn’t the case for the Mobilise-D technical validation study (TVS) where 120 participants with chronic obstructive pulmonary disease, Parkinson’s disease, multiple sclerosis, congestive heart failure or hip fracture, along with healthy older adults, will be enrolled. Our test sites in Newcastle and Sheffield have found a way to work around the distancing restrictions to keep the study open, and confirmed that the technical validation…

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[Publication] Toward a Regulatory Qualification of Real-World Mobility Performance Biomarkers in Parkinson’s Patients Using Digital Mobility Outcomes

Today’s smartwatches and activity bracelets, like FitBit, Apple, and Samsung, have motion sensors that can measure your daily activity. These technologies can tell you how much or little active you are, for example by counting your daily number of steps, heart rate or track your movements with GPS. In both basic and clinical research, similar…

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– I felt Mobilise-D!

REAL WORLD STORIES – Episode 1 Mobility – how well people walk – is an important marker of health. With advanced age, as well as disease and injury, mobility challenges often become prominent. The COVID-19 breakout and the subsequent lockdowns all over the world put severe restrictions on everyone’s mobility. However, as it turns out,…

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[VIDEO] Introducing the Mobilise-D Clinical Trials

One of the many impacts of the COVID-19 lockdown earlier this year, has been the severe restrictions on mobility of both patients and the public. Furthermore, the ability to assess patients’ mobility has suffered as well because of the barriers created between researchers and participants. Being able to remotely monitor patients’ mobility in their natural…

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Mobilise-D’s Claudia Mazzà receives Suffrage Science award 2020!

The Mobilise-D Consortium is incredibly proud that our own WP2 star academic leader, Professor Claudia Mazzà from the University of Sheffield, is a recipient of the Suffrage Science award, celebrating women in science for their scientific achievements and their ability to inspire others. The Suffrage Science scheme was founded by the Medical Research Council’s London Institute…

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Mobilise-D well represented at the Virtual Physiological Human Conference 2020

The Virtual Physiological Human Conference (VPH2020) was held online August 24-28 with several representatives from the Mobilise-D consortium. This year, the focus was on “When models, methods & experiments meet the clinic”. Prof. Claudia Mazzà from the University of Sheffield, Mobilise-D’s Academic Lead of WP2 – Algorithm development and technical validation, chaired the session “Monitoring &…

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Mobilise-D Technical Validation Study has started!

We are tremendously proud to announce that the Mobilise-D Technical Validation Study has officially started recruiting subjects! After the unprecedented times of COVID-19 lock-down that affected the entire world, we are now in a position to come back safely and restart our research in clinical settings. COVID-19 times are not over yet, and therefore we…

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Protocol paper for Mobilise-D scoping review published

Walking limitations are debilitating symptoms in many chronic diseases, and are highly related to quality of life, fall risk, and economic burden. Unsurprisingly, walking ability is a common target of pharmacological or behavioural intervention. Thanks to advances in wearable sensor technologies, it is now possible to objectively monitor how, and how much, patients walk in…

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VIDEO: Mobilise-D matters – now more than ever!

The large-scale social and behavioural changes that happened almost overnight in our day-to-day life due to COVID-19, illustrate the importance of anticipating and developing new ways of patient care. Especially mobility is a telling sign of how well a patient is doing. “Mobility is something that we take for granted until we lose it. And…

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Walking in the lab and a real-world environment with Multiple Sclerosis

Our colleagues from Tel Aviv, the TASMC Mobilisers, studied the quality of walking of people with multiple sclerosis and healthy controls in two environments: a) a well-structured laboratory setting and b) during real-life, everyday walking using 24/7 monitoring.  During every-day walking, the patients took fewer steps, they walked more slowly, and the quality of their…

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New algorithm for gait detection published

FAU-Mobilisers publish a novel algorithm for the detection of gait from continuous inertial sensor data. The approach allows an efficient and precise processing of real-life gait data. This will facilitate the clinical application of mobile gait analysis in free-living conditions. Read the full paper here.

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New publication on gait variability in Huntington’s disease

The expertise of our Mobilisers goes far beyond the Mobilise-D patient groups. Ultimately our findings should benefit anyone with mobility challenges, such as people suffering from Huntington’s Disease. Heiko Gaßner and colleagues explain more in their paper investigating gait variability as digital biomarkers of severity in Huntington’s disease. In this study, characteristic features of gait…

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Technical validation training in Newcastle

The Mobilise-D technical validation training in Newcastle is happening this week (February 24-26th), and Mobilisers from Newcastle and Northumbria University are focused and ready to learn. With assistance from the Universities of Sassari and Sheffield, the Mobilise-D assessors will get a firm grasp on how to properly set up the necessary equipment and how to…

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Center-stage presence of Mobilise-D at the 2020 MobEx Meeting

Mobilise-D featured prominently at this year’s Mobility and Exercise in the Elderly (MobEx) meeting in Bologna, Italy, through two dedicated sessions, one with technical and one with clinical perspectives. MobEx is an annual meeting where a dedicated network of researchers in the fields of mobility, exercise, and their measurement meets and shares experiences, challenges, and…

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Technical validation training session

This January, researchers, academics and clinicians from all over Europe and Israel were welcomed to the Insigneo Motion Capture and Virtual Reality Laboratory at the University of Sheffield for a training session for all the universities and hospitals involved in Work Package 2 ‘Technical validation of a single sensor system’ of the Mobilise-D project. The…

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Invited Mobilise-D Symposium at the Congress of the International Society of Biomechanics in Calgary, Canada

August 3rd 2019 an invited symposium titled “Inertial Measurement Units based methods for mobility assessment in real-world condition” was held at the Congress of the International Society of Biomechanics (ISB) in Calgary, Canada. The aim of the symposium was to survey the most challenging methods, sensor configurations and techniques to detect walking bouts and estimate…

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[Press release] Ground-breaking €50 million digital monitoring project to tackle mobility loss

Imagine being able to monitor patients’ mobility and health with the help of small sensors and personalized algorithms – on a daily basis, without them having to come to a clinic regularly and at predetermined intervals. Impossible? Not according to the Innovation in Medicine Initiative (https://www.imi.europa.eu/), who dedicated 25.4 million euro public money to Mobilise-D,…

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Kick-off Meeting in Newcastle, April 11th 2019

The Mobilise-D project had its official start April 1st this year and on April 11th, the consortium got together to kick the project off to a good start. More than 100 Mobilisers met in Newcastle to better get to know both the project and each other, and to build a strong team that can handle…

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